Reaktion #514592

Reaktionsgleichung

AlCl3

1-cyclohexenecarboxylic acid

HCl

→

titled compound

Ausbeute 76.5%

4-Phenyl-cyclohexanecarboxylic acid

Ausbeute 76.5%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigekept at 35° C.
2. 2
   workup.ADDITIONAfter addition
3. 3
   TemperaturThe reaction was cooled
4. 4
   ExtraktionThe product was extracted with EtOAc
5. 5
   ExtraktionThe organic layer was extracted with 1 N NaOH
6. 6
   Sonstigeto produce a white precipitate that
7. 7
   Filtrationwas collected by filtration
8. 8
   Waschenwashed with water
9. 9
   Sonstigedried

Vorschrift

To a mixture of AlCl3 (13 g, 97.5 mmol, 1.0 equiv) in benzene (100 mL) kept at 35° C., was added 1-cyclohexenecarboxylic acid (5 g, 39.7 mmol, 0.41 equiv) dropwise. After addition was complete, the reaction solution was heated to 70° C. for 1 h and 45° C. overnight. The reaction was cooled, and 200 mL of 1 N HCl was slowly added. The product was extracted with EtOAc. The organic layer was extracted with 1 N NaOH and the aqueous layer was acidified with concentrated HCl to produce a white precipitate that was collected by filtration, washed with water and dried to give the titled compound as a white solid (3.1 g, 38%) which was used without further purification.

Quelle