Reaktion #51424

Reaktionsgleichung

water

4-Nitro-1H-pyrrole-2-carboxylic acid ethyl ester

sodium ethoxide

1-bromo-3-methylbutane

→

product

Ausbeute 29.0%

1-(3-Methyl-butyl)-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester

Ausbeute 29.0%

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred
2. 2
   Temperaturat reflux for 6 h
3. 3
   Temperaturcooled to room temperature
4. 4
   SonstigeThe pale yellow precipitates
5. 5
   Filtrationwere collected by filtration
6. 6
   Waschenwashed with water
7. 7
   Sonstigedried

Vorschrift

4-Nitro-1H-pyrrole-2-carboxylic acid ethyl ester (3.69 g, 20.04 mmol) was dissolved in 100 ml of hot anhydrous ethanol and the solution was cooled to room temperature. 30 ml of sodium ethoxide (about 1M) in ethanol was added. The reaction mixture was stirred at room temperature for 20 min and 1-bromo-3-methylbutane (8 ml) was added. The mixture was stirred at reflux for 6 h and cooled to room temperature and then poured into water. The pale yellow precipitates were collected by filtration, washed with water, and dried to give the product (1.48 g, 29%).

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