Reaktion #51393

ord-759f28cc195f45dcac582d3bf1a38aaf

Reaktionsgleichung

O=C(O)CC1CCCC1
cyclopentylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CC(C)COC(=O)[C@H](C)NC(=O)CC1CCCC1
title compound
CC(C)COC(=O)[C@H](C)NC(=O)CC1CCCC1
N-(cyclopentylacetyl)-L-alanine iso-butyl ester

Edukte

O=C(O)CC1CCCC1
cyclopentylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe reaction was monitored by tlc on silica gel (Rf=0.37 in 1:3 EtOAc:hexane) and purification
  2. 2
    Extraktionwas by extraction with Et2O

Vorschrift

Following General Procedure BB above, and using cyclopentylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 62° C.-64° C. The reaction was monitored by tlc on silica gel (Rf=0.37 in 1:3 EtOAc:hexane) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02