Reaktion #51385

ord-209596de7e474acba203eff5226a0931

Reaktionsgleichung

Cc1ccc(CC(=O)O)cc1
4-methylphenylacetic acid
CC(C)COC(=O)[C@H](C)N
L-alanine iso-butyl ester
→
Cc1ccc(CC(=O)N[C@@H](C)C(=O)OCC(C)C)cc1
title compound
Cc1ccc(CC(=O)N[C@@H](C)C(=O)OCC(C)C)cc1
N-[(4-methylphenyl)acetyl]-L-alanine iso-butyl ester

Edukte

Cc1ccc(CC(=O)O)cc1
4-methylphenylacetic acid
CC(C)COC(=O)[C@H](C)N
L-alanine iso-butyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Filtrationwas by filtration

Vorschrift

Following General Procedure BI above, and using 4-methylphenylacetic acid (Aldrich) and L-alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02