Reaktion #51376

ord-3e99e35af0dc4e44b84f850154f8b329

Reaktionsgleichung

CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)O
N-Phenylacetyl-L-leucine
CC(C)CO
iso-butyl alcohol
→
CC(C)COC(=O)[C@H](CC(C)C)NC(=O)Cc1ccccc1
N-(phenylacetyl)-L-leucine iso-butyl ester

Edukte

CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)O
N-Phenylacetyl-L-leucine
CC(C)CO
iso-butyl alcohol

Reagenzien

Keine

Lösungsmittel

ClC(Cl)Cl
CHCl3

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Filtrationfiltered through a plug of cotton
  2. 2
    Sonstigethe filtrate evaporated at reduced pressure to an oil which

Vorschrift

N-Phenylacetyl-L-leucine (0.0081 g, 0.038 mmol) was dissolved in 2.0 mL CHCl3 (EtOH free) and iso-butyl alcohol (0.055 mL) and treated with P-EPC (100 mg, 0.87 milliequivalents). The mixture was rotated for 4 days, filtered through a plug of cotton and the filtrate evaporated at reduced pressure to an oil which was sufficiently pure for testing.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02