Reaktion #51374

ord-234b2d2cfd5742799503095206a222bd

Reaktionsgleichung

CC(C)[C@H](NC(=O)Cc1ccccc1)C(=O)O
N-(phenylacetyl) valine
CCC(C)CO
2-methylbutan-1-ol
→
CCC(C)COC(=O)[C@@H](NC(=O)Cc1ccccc1)C(C)C
title compound
CCC(C)COC(=O)[C@@H](NC(=O)Cc1ccccc1)C(C)C
N-(phenylacetyl)valine 2-methylbutyl ester

Edukte

CC(C)[C@H](NC(=O)Cc1ccccc1)C(=O)O
N-(phenylacetyl) valine
CCC(C)CO
2-methylbutan-1-ol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Filtrationwas by filtration

Vorschrift

Following General Procedure BC and using the N-(phenylacetyl) valine prepared in Step A above and 2-methylbutan-1-ol (Aldrich), the title compound was prepared as a diastereomeric mixture. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02