Reaktion #51372

ord-01993111ebdf4eef835a7c3166fdf998

Reaktionsgleichung

O=C(O)Cc1ccccc1
phenylacetic acid
CCC(N)C(=O)OCC(C)C
iso-butyl 2-aminobutyrate
→
CCC(NC(=O)Cc1ccccc1)C(=O)OCC(C)C
title compound
CCC(NC(=O)Cc1ccccc1)C(=O)OCC(C)C
2-(phenylacetamido)butyric acid iso-butyl ester

Edukte

O=C(O)Cc1ccccc1
phenylacetic acid
CCC(N)C(=O)OCC(C)C
iso-butyl 2-aminobutyrate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following General Procedure BH above and using phenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above) the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by chromatography on silica gel using 9:1 toluene: EtOAc as the eluant.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02