Reaktion #51353

ord-98a930e9e2f64f74b4a6d834a5c41671

Reaktionsgleichung

O=C(Cl)Cc1ccccc1
phenylacetyl chloride
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CC(C)COC(=O)[C@H](C)NC(=O)Cc1ccccc1
title compound
CC(C)COC(=O)[C@H](C)NC(=O)Cc1ccccc1
N-(phenylacetyl)-L-alanine iso-butyl ester

Edukte

O=C(Cl)Cc1ccccc1
phenylacetyl chloride
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Extraktionwas by extraction with Et2O

Vorschrift

Following General Procedure BB and using phenylacetyl chloride (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 45°-47° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02