Reaktion #51347

Reaktionsgleichung

4-methylphenylacetic acid

D,L-alanine iso-butyl ester hydrochloride

→

title compound

N-[(4-methylphenyl)acetyl]-D,L-alanine iso-butyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification
2. 2
   Extraktionwas by extraction with Et2O

Vorschrift

Following General Procedure BB and using 4-methylphenylacetic acid (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 102°-104° C. The reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Quelle