Reaktion #51346

ord-7d225e1005844bdd97d5e8ce53944117

Reaktionsgleichung

O=C(O)Cc1ccc(Cl)c(Cl)c1
3,4-dichlorophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CC(C)COC(=O)[C@H](C)NC(=O)Cc1ccc(Cl)c(Cl)c1
title compound
CC(C)COC(=O)[C@H](C)NC(=O)Cc1ccc(Cl)c(Cl)c1
N-[(3,4-dichlorophenyl)acetyl]-L-alanine iso-butyl ester

Edukte

O=C(O)Cc1ccc(Cl)c(Cl)c1
3,4-dichlorophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Extraktionwas by extraction with Et2O

Vorschrift

Following General Procedure BB and using 3,4-dichlorophenylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 81°-83° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02