Reaktion #51344

ord-243dad5af2fa495b99fb5dd87315a0be

Reaktionsgleichung

CCC(C)CC(=O)O
3-methylpentanoic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CCC(C)CC(=O)N[C@@H](C)C(=O)OCC(C)C
title compound
CCC(C)CC(=O)N[C@@H](C)C(=O)OCC(C)C
N-(3-methylpentanoyl)-L-alanine iso-butyl ester

Edukte

CCC(C)CC(=O)O
3-methylpentanoic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Extraktionwas by extraction with Et2O

Vorschrift

Following General Procedure BB and using 3-methylpentanoic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02