Reaktion #513422

Reaktionsgleichung

Acetic acid 2-methyl-pyridin-4-ylmethyl ester

ammonium hydroxide

→

(2-methyl-pyridin-4-yl)-methanol

Ausbeute 94.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige, the mixture was evaporated in vacuo
2. 2
   Sonstigethe residue was purified by silica gel column chromatography (eluent, EA)

Vorschrift

Acetic acid 2-methyl-pyridin-4-ylmethyl ester (5.1 g, 31 mmol) was stirred with ammonium hydroxide (10 ml) in methanol (25 ml) at room temperature. After 24 hr., the mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography (eluent, EA) to afford 3.56 g (94%) of (2-methyl-pyridin-4-yl)-methanol as a pale yellow solid. m.p. 58-59° C. 1H NMR (200 MHz, CDCl3) δ 2.45 (3H, s), 4.66 (2H, s), 7.06 (1H, d, J=5.2 Hz), 7.14 (1H, s), 8.25 (1H, d, J=5.2 Hz).

Quelle