Reaktion #51334

ord-5197e12bfb334a10b3329c8112e9cee0

Reaktionsgleichung

Nc1ccc2ccccc2c1
2-aminonaphthalene
CCOC(=O)C(C)=O
ethyl pyruvate
→
CCOC(=O)[C@H](C)Nc1ccc2ccccc2c1
title compound
CCOC(=O)[C@H](C)Nc1ccc2ccccc2c1
N-(2-naphthyl)alanine ethyl ester

Edukte

Nc1ccc2ccccc2c1
2-aminonaphthalene
CCOC(=O)C(C)=O
ethyl pyruvate

Reagenzien

Keine

Lösungsmittel

—
EtOAc hexanes

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePurification

Vorschrift

Following reductive amination General Procedure AA above and using 2-aminonaphthalene (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared as a solid having a melting point of 52-56° C. The reaction was monitored by silica gel tlc (Rf=0.50 in 25% EtOAc/hexanes). Purification was by flash chromatography with silica gel using 25% EtOAc/hexanes as the eluant.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02