Reaktion #513316

Reaktionsgleichung

Compound ( 60 )

(3,5-Dichloro-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone

→

title compound

Ausbeute 87.3%

6-(3,5-Dichloro-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Ausbeute 87.3%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe white precipitate was collected by filtration
2. 2
   Waschenwashed with cold water
3. 3
   Sonstigedried in high vacuo

Vorschrift

Compound (60) (2.0 g, 5.6 mmol) was refluxed with conc. HCl (30 ml) for 3 hr. After cooling to room temperature, the white precipitate was collected by filtration, washed with cold water, and dried in high vacuo to afford 1.6 g (87%) of the title compound as a white solid. m.p. 252-253° C.; 1H NMR (200 MHz, CDCl3/CD3OD) δ 1.11 (6H, d, J=6.9 Hz), 2.33 (1H, m), 7.61-7.73 (3H, m); HRMS (EI) Calcd. 326.0225, Found 326.0240.

Quelle