Reaktion #51331

Reaktionsgleichung

3,4-methylenedioxyaniline

methyl pyruvate

N-(3,4-methylenedioxyphenyl)alanine methyl ester

→

title compound

N-(3,4-methylenedioxyphenyl)alanine iso-butyl ester

Lösungsmittel

iso-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas prepared

Vorschrift

Following reductive amination General Procedure AA above and using 3,4-methylenedioxyaniline (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-methylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above and using iso-butanol to provide the title compound as an oil. The reaction was monitored by silica gel tlc (Rf=0.61 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography with silica gel using 25% EtOAc/hexanes as the eluant.

Quelle