Reaktion #51329

ord-2074f13ed9154ebd816f5085613c9c96

Reaktionsgleichung

Nc1ccc2ccccc2c1
2-aminonaphthalene
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate
→
CC(C)COC(=O)[C@H](C)Nc1ccc2ccccc2c1
title compound
CC(C)COC(=O)[C@H](C)Nc1ccc2ccccc2c1
N-(2-naphthyl)alanine iso-butyl ester

Edukte

Nc1ccc2ccccc2c1
2-aminonaphthalene
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePurification

Vorschrift

Following General Procedure AA above and using 2-aminonaphthalene (Aldrich) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared as an oil. Purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02