Reaktion #513167

Reaktionsgleichung

2-Fluoro-4-(trifluoromethyl)benzoyl chloride

pyridine

7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one

→

2-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethyl)benzamide

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGby stirring for 30 minutes
2. 2
   Filtrationthe precipitated crystals were collected by filtration

Vorschrift

2-Fluoro-4-(trifluoromethyl)benzoyl chloride was added to a pyridine solution of 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one, followed by stirring at room temperature for 12 hours. Water was added to the reaction liquid, followed by stirring for 30 minutes and then the precipitated crystals were collected by filtration to obtain 2-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethyl)benzamide.

Quelle