Reaktion #51306

Reaktionsgleichung

3,4-dichloroaniline

isopropyl pyruvate

→

title compound

N-(3,4-dichlorophenyl)alanine iso-propyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification

Vorschrift

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and isopropyl pyruvate (prepared by following General Procedure AO above using isopropanol in place of iso-butanol), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Quelle