Reaktion #513025

ord-2cdf3f5987e842549d8dffcf6e39dbad

Reaktionsgleichung

Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2CC(C)C[C@@H]21
6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide
Cc1nc(C(=O)O)c(-c2cccc(F)c2)s1
5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid
→
Cc1nc(C(=O)N2C[C@@H]3CC(C)C[C@@H]3[C@H]2CNC(=O)c2c(C)nc3sccn23)c(-c2cccc(F)c2)s1
6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-{3-[5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl}-amide

Edukte

Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2CC(C)C[C@@H]21
6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide
Cc1nc(C(=O)O)c(-c2cccc(F)c2)s1
5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide with 5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08106215B2uspto-grants-2012_01