Reaktion #51299

Reaktionsgleichung

iso-butanol

pyridine

2-bromopropionyl bromide

→

title compound

Iso-butyl 2-bromopropionate

Lösungsmittel

diethyl ether

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with 1N HCl, water, aqueous NaHCO3, brine
2. 2
   Trocknendried over magnesium sulfate or sodium sulfate
3. 3
   SonstigeRemoval of the solvents at reduced pressure

Vorschrift

To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.

Quelle