Reaktion #512985

ord-f7b0212d584b469c98d70d25bb4cd4d4

Reaktionsgleichung

CC1C[C@H]2CN(C(=O)OC(C)(C)C)[C@H](CN)[C@H]2C1
(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester
Cc1nc2sccn2c1C(=O)O
6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid
→
Cc1nc2sccn2c1C(=O)NC[C@@H]1[C@H]2CC(C)C[C@H]2CN1C(=O)OC(C)(C)C
(1S,2S,5R)-2-{[6-Methyl-(imidazo[2,1-b]thiazole-5-carbonyl)-amino]-methyl}-7-methyl-3-aza-bicyclo[3.3.0]octane-3-carboxylic acid tert.-butyl ester

Edukte

CC1C[C@H]2CN(C(=O)OC(C)(C)C)[C@H](CN)[C@H]2C1
(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester
Cc1nc2sccn2c1C(=O)O
6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of (1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester with commercially available 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08106215B2uspto-grants-2012_01