Reaktion #512971

ord-2a2e31dfbe1d494cb5c968f25b8d5a12

Reaktionsgleichung

COC(=O)C(=O)C(Cl)c1ccc(F)cc1
3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester
NC(N)=S
thiourea
→
COC(=O)c1nc(N)sc1-c1ccc(F)cc1
2-Amino-5-(4-fluoro-phenyl)-thiazole-4-carboxylic acid methyl ester

Edukte

COC(=O)C(=O)C(Cl)c1ccc(F)cc1
3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester
NC(N)=S
thiourea

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester with thiourea. LC-MS: tR=0.75 min; [M+H]+=253.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08106215B2uspto-grants-2012_01