Reaktion #512969

ord-f0374b7ee67346e29c07d6986271e4b4

Reaktionsgleichung

COC(=O)C(=O)C(Cl)c1cccc(C)c1
3-chloro-2-oxo-3-m-tolyl-propionic acid methyl ester
NC(N)=S
thiourea
→
COC(=O)c1nc(N)sc1-c1cccc(C)c1
2-Amino-5-m-tolyl-thiazole-4-carboxylic acid methyl ester

Edukte

COC(=O)C(=O)C(Cl)c1cccc(C)c1
3-chloro-2-oxo-3-m-tolyl-propionic acid methyl ester
NC(N)=S
thiourea

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 3-chloro-2-oxo-3-m-tolyl-propionic acid methyl ester with thiourea. LC-MS: tR=0.78 min; [M+H]+=249.0.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08106215B2uspto-grants-2012_01