Reaktion #51296

ord-4925e8544ee04f8dbe2b5bf9ea58b95b

Reaktionsgleichung

CC(N)C(=O)O
D,L-alanine
O=S(Cl)Cl
thionyl chloride
CC(C)CO
iso-butanol
→
CC(C)COC(=O)C(C)N.Cl
title compound
CC(C)COC(=O)C(C)N.Cl
D,L-alanine iso-butyl ester hydrochloride

Edukte

CC(N)C(=O)O
D,L-alanine
O=S(Cl)Cl
thionyl chloride
CC(C)CO
iso-butanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturwas refluxed for 1.5 hours
  2. 2
    SonstigeThe volatiles were removed at reduced pressure at 90° C. under reduced pressure

Vorschrift

A mixture of 35.64 g (0.4 mol) of D,L-alanine (Aldrich), 44 mL (0.6 mol) of thionyl chloride (Aldrich) and 200 mL of iso-butanol was refluxed for 1.5 hours. The volatiles were removed at reduced pressure at 90° C. under reduced pressure to give the title compound as an oil, which was used without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02