Reaktion #51293

ord-5ab1731a61c04d56b1d251826165876c

Reaktionsgleichung

3,5-difluorophenylacetic acid

COC(=O)C1(Cc2ccccc2)CN(C(=O)OC(C)(C)C)C(C(C)N)=N1

1-tert-butoxycarbonyl-2-(1-aminoethyl)-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline

2-(1-aminoethyl)-1-tert-butoxycarbonyl-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline

→

COC(=O)C1(Cc2ccccc2)CN(C(=O)OC(C)(C)C)C(C(C)NC(=O)Cc2cc(F)cc(F)c2)=N1

title compound

1-tert-butoxycarbonyl-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline

Edukte

3,5-difluorophenylacetic acid

1-tert-butoxycarbonyl-2-(1-aminoethyl)-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline

2-(1-aminoethyl)-1-tert-butoxycarbonyl-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline

—

hexanes EtOAc

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
Sonstigethe product was purified by flash column chromatography

Vorschrift

Following General Procedure C above and using 3,5-difluorophenylacetic acid (Aldrich) and 1-tert-butoxycarbonyl-2-(1-aminoethyl)-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline (Example J), the title compound was prepared as an amorphous solid. The reaction was monitored by tlc (Rf=0.34 in 2:1 hexanes/EtOAc) and the product was purified by flash column chromatography.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02