Reaktion #51291

ord-4603fdb65ae248febb22cc11c07a9866

Reaktionsgleichung

Nc1cc(F)cc(F)c1
3,5-difluoroaniline
CC(Cl)C(=O)O
2-chloropropionic acid
→
C[C@H](Nc1cc(F)cc(F)c1)C(=O)O
N-(3,5-difluorophenyl)alanine

Edukte

Nc1cc(F)cc(F)c1
3,5-difluoroaniline
CC(Cl)C(=O)O
2-chloropropionic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the procedure set forth in U.S. Pat. No. 3,598,859 and Example Q above, N-(3,5-difluorophenyl)alanine was prepared using 3,5-difluoroaniline (Aldrich) and 2-chloropropionic acid (Aldrich).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02