Reaktion #5128

Reaktionsgleichung

benzoyl chloride

ammonium thiocyanate

cyclohexylamine

→

Cyclohexylthiourea

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter refluxing for 10 minutes
2. 2
   Temperaturthe mixture was refluxed for a further 20 minutes
3. 3
   Sonstigethe water was decanted off the oily product
4. 4
   workup.DISSOLUTIONThe residue was dissolved in a hot mixture of 2 1 of 10% strength sodium hydroxide solution and 500 ml of ethanol
5. 5
   Temperaturrefluxed for 30 minutes
6. 6
   workup.ADDITIONThe reaction mixture was then diluted with ice-water
7. 7
   FiltrationThe resulting precipitate was filtered off with suction
8. 8
   Waschenwashed with water
9. 9
   Sonstigedried at 80° C. under reduced pressure

Vorschrift

295.5 g (2.1 mol) of benzoyl chloride were added dropwise over the course of 10 minutes to a solution of 165.0 g (2.2 mol) of ammonium thiocyanate in 500 ml of absolute acetone. After refluxing for 10 minutes, 198.9 g (2.0 mol) of cyclohexylamine were added dropwise, and the mixture was refluxed for a further 20 minutes. It was then stirred into 4 1 of ice-water, and the water was decanted off the oily product. The residue was dissolved in a hot mixture of 2 1 of 10% strength sodium hydroxide solution and 500 ml of ethanol and refluxed for 30 minutes. The reaction mixture was then diluted with ice-water, and the pH was adjusted initially to 1 with concentrated hydrochloric acid and then to 9 with solid sodium bicarbonate. The resulting precipitate was filtered off with suction, washed with water and dried at 80° C. under reduced pressure.

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