Reaktion #51258

Reaktionsgleichung

product

8-amino-1-{4-[(aminothio)peroxy]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

NMP

→

title compound

Ausbeute 90.5%

8-amino-1-{4-[(aminothio)peroxy]phenyl}-1H-benzo[g]indazole-3-carboxamide

Ausbeute 90.5%

Lösungsmittel

cumene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 16 h
2. 2
   FiltrationThe mixture was then filtered
3. 3
   Einengenconcentrated
4. 4
   workup.ADDITIONThe residue was diluted with methanol (10 mL)
5. 5
   workup.ADDITIONadded to water, after 1 h the resulting precipitate
6. 6
   Filtrationwas collected by filtration
7. 7
   Sonstigedried

Vorschrift

The product of Example 4b (1 g) and 5% Pd/C (300 mg) suspended in cumene (50 mL) and NMP (5 mL) was heated at reflux for 16 h. The mixture was then filtered and concentrated. The residue was diluted with methanol (10 mL) and added to water, after 1 h the resulting precipitate was collected by filtration and dried to yield the title compound (0.9 g).

Quelle