Reaktion #51242

Reaktionsgleichung

sodium bicarbonate

ethyl glycolate

sodium hydride

1,4-dibromobutane

→

(4-Bromo-butoxy)-acetic Acid Ethyl Ester

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Trocknenthe organic layer was dried over anhydrous sodium sulfate
2. 2
   Einengenconcentrated
3. 3
   Sonstigethe residue was purified by chromatography
4. 4
   Sonstigeto afford a colorless oil

Vorschrift

To a solution of sodium hydride in 40 mL DMF stirred at 0° C. was slowly added ethyl glycolate (5 g, 48 mmol). After 1 hour, 1,4-dibromobutane (8.6 mL, 72 mmol) was added, and the mixture was stirred for an additional 2 hours. The reaction was allowed to warm to room temperature for an additional 3 hours. A sodium bicarbonate solution was added, and the organic layer was dried over anhydrous sodium sulfate, concentrated and the residue was purified by chromatography to afford a colorless oil.

Quelle