Reaktion #51231

Reaktionsgleichung

N-tert-butoxycarbonyl-4-dimethylaminopiperidine

triacetoxyborohydride

4-(tert-butoxycarbonyl)piperidone

hydrochloric acid

Dimethylamine hydrochloride

→

4-(dimethylamino)piperidine.dihydrochloride

Lösungsmittel

triethylamine

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder ice-cooling
2. 2
   Sonstigereaction

Vorschrift

Dimethylamine hydrochloride (430 mg) was added to a methylene chloride (10 ml) solution containing 4-(tert-butoxycarbonyl)piperidone (1.0 g), and under ice-cooling, triethylamine (0.84 ml) and triacetoxyborohydride (1.17 g) were further added thereto, and the mixture was stirred at room temperature for 3 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-4-dimethylaminopiperidine. This compound was acid-treated with hydrochloric acid to obtain 4-(dimethylamino)piperidine.dihydrochloride.

Quelle