Reaktion #511871

ord-65438661eed044b19953d0a9870f5aaf

Reaktionsgleichung

Cc1cccc(CSc2nc(N[C@H](C)CO)cc(NS(C)(=O)=O)n2)c1F
subtitle product
Cc1cccc(CSc2nc(N[C@H](C)CO)cc(NS(C)(=O)=O)n2)c1F
N-(2-[(2-Fluoro-3-methylbenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-pyrimidin-4-yl)methanesulfonamide
CC(C)(N)CO
2-amino-2-methyl-1 propanol
O=C(O)C(F)(F)F
trifluoroacetic acid
→
Cc1cccc(CSc2nc(NC(C)(C)CO)cc(NS(C)(=O)=O)n2)c1F
title compound
Cc1cccc(CSc2nc(NC(C)(C)CO)cc(NS(C)(=O)=O)n2)c1F
N-{2-[(2-Fluoro-3-methylbenzyl)thio]-6-[(2-hydroxy-1,1-dimethylethyl)amino]-pyrimidin-4-yl}methanesulfonamide

Edukte

Cc1cccc(CSc2nc(N[C@H](C)CO)cc(NS(C)(=O)=O)n2)c1F
subtitle product
Cc1cccc(CSc2nc(N[C@H](C)CO)cc(NS(C)(=O)=O)n2)c1F
N-(2-[(2-Fluoro-3-methylbenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-pyrimidin-4-yl)methanesulfonamide
CC(C)(N)CO
2-amino-2-methyl-1 propanol
O=C(O)C(F)(F)F
trifluoroacetic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared as a white solid by the method of Example 115 using the subtitle product of Example 115 step (1.0 g), 2-amino-2-methyl-1 propanol (1.5 ml) and trifluoroacetic acid (2 ml). Yield: 0.19 g.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08106063B2uspto-grants-2012_01