Reaktion #51182

ord-2dcac970ba41443aa25c723595a5a9dc

Reaktionsgleichung

O=C(O)CC(NC(=O)C1CC(=O)N(c2cccc(NC(=O)NCc3ccccc3)c2)C1)c1cccc(F)c1
3-(3-fluorophenyl)-3-{(5-oxo-1-(3-{(benzylamino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid
CCOC(=O)CC(N)c1cc(Cl)cc(Cl)c1O
ethyl 3-amino-3-(3,5-dichloro-2-hydroxyphenyl)propanoate
NCc1cccs1
2-thienylmethyl amine
→
O=C(O)CC(NC(=O)C1CC(=O)N(c2cccc(NC(=O)NCc3cccs3)c2)C1)c1cc(Cl)cc(Cl)c1O
title compound
O=C(O)CC(NC(=O)C1CC(=O)N(c2cccc(NC(=O)NCc3cccs3)c2)C1)c1cc(Cl)cc(Cl)c1O
3-(3,5-dichloro-2-hydroxyphenyl)-3-{(5-oxo-1-(3-{((2-thienylmethyl)amino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid

Edukte

O=C(O)CC(NC(=O)C1CC(=O)N(c2cccc(NC(=O)NCc3ccccc3)c2)C1)c1cccc(F)c1
3-(3-fluorophenyl)-3-{(5-oxo-1-(3-{(benzylamino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid
CCOC(=O)CC(N)c1cc(Cl)cc(Cl)c1O
ethyl 3-amino-3-(3,5-dichloro-2-hydroxyphenyl)propanoate
NCc1cccs1
2-thienylmethyl amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was analogously synthesized to the preparation of 3-(3-fluorophenyl)-3-{(5-oxo-1-(3-{(benzylamino)carbonylamino}phenyl)pyrrolidin-3-yl)carbonylamino}propanoic acid from ethyl 3-amino-3-(3,5-dichloro-2-hydroxyphenyl)propanoate and 2-thienylmethyl amine. MS (ES+): 591 (M+H)+; (ES−): 589 (M−H)−.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849639B2uspto-grants-2005_02