Reaktion #51178

ord-b8c8c4831cee469d8d34ab9f9ec96606

Reaktionsgleichung

C1CCOC1.CO.O.[Na+].[OH-]
NaOH water THF MeOH
COC(=O)C1CC(=O)N(c2cccc(CNc3ccccn3)c2)C1
methyl 5-oxo-1-{3-((2-pyridylamino)methyl)phenyl}pyrrolidine-3-carboxylate
[Na+].[OH-]
NaOH
→
O=C(O)C1CC(=O)N(c2cccc(CNc3ccccn3)c2)C1
5-oxo-1-{3-((2-pyridylamino)methyl)phenyl}pyrrolidine-3-carboxylic acid

Edukte

C1CCOC1.CO.O.[Na+].[OH-]
NaOH water THF MeOH
COC(=O)C1CC(=O)N(c2cccc(CNc3ccccn3)c2)C1
methyl 5-oxo-1-{3-((2-pyridylamino)methyl)phenyl}pyrrolidine-3-carboxylate
[Na+].[OH-]
NaOH

Reagenzien

Keine

Lösungsmittel

C1CCOC1.CO.O
water THF MeOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Einengenconcentrated in vacuo
  2. 2
    SonstigeThe compound was used in the next step without further purification

Vorschrift

To a solution of methyl 5-oxo-1-{3-((2-pyridylamino)methyl)phenyl}pyrrolidine-3-carboxylate in water/THF/MeOH was added 1.0 eq 1N NaOH. The volume ratio of NaOH/water/THF/MeOH was 1:3:4:4. The reaction was stirred at room temperature overnight, and then concentrated in vacuo. The compound was used in the next step without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849639B2uspto-grants-2005_02