Reaktion #51164

Reaktionsgleichung

4,6-Dihydroxy-2-methylpyrimidine

nitric acid

→

4,6-dihydroxy-2-methyl-5-nitropyrimidine

Ausbeute 15.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred for 2 hours
2. 2
   Filtrationthe precipitated crystal was filtered
3. 3
   Sonstigedried

Vorschrift

4,6-Dihydroxy-2-methylpyrimidine (1.0 g, 7.9 mmol) was added gradualy to ice-cooled fuming nitric acid (3 ml) stirring. The mixture was stirred for 2 hours cooling with ice and for 1 hour at the room temperature, and then the precipitated crystal was filtered and dried to obtain 207 mg (yield 15%) of 4,6-dihydroxy-2-methyl-5-nitropyrimidine.

Quelle