Reaktion #511571

Reaktionsgleichung

1-Bromodecane

Diethyl ether

sodium hydride

trityl ether

water

→

clear liquid

Ausbeute 52.0%

3-Dodecyloxy-2-decyloxy-1-triphenylmethoxypropane

Ausbeute 52.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   Temperaturheat
3. 3
   Sonstige(55° C.)
4. 4
   Temperaturheating
5. 5
   workup.WAITwas continued for 6 hours
6. 6
   TemperaturAfter cooling for 3 hours
7. 7
   Waschenthe solution washed with 15 percent sodium thiosulfite, water, and brine
8. 8
   TrocknenAfter drying over sodium sulfate
9. 9
   Sonstigethe ether was removed
10. 10
    Sonstigethe residue was chromatographed with a gradient of hexanes:ethyl acetate (100:0 to 20:1)

Vorschrift

The trityl ether of Section B (13.5 g, 0.027 mol) was added dropwise to an ice-cooled suspension of sodium hydride (80%, 1.6 g, 0.054 mol) in 150 ml of tetrahydrofuran under nitrogen. After stirring for 2 hours at room temperature, heat was applied (55° C.). 1-Bromodecane (6 g, 0.027 mol) was added dropwise; heating was continued for 6 hours. After cooling for 3 hours, water was added slowly. Diethyl ether (2×100 mL) was added, and the solution washed with 15 percent sodium thiosulfite, water, and brine. After drying over sodium sulfate, the ether was removed, and the residue was chromatographed with a gradient of hexanes:ethyl acetate (100:0 to 20:1) to give 9 g (52%) of a clear liquid.

Quelle