Reaktion #51108

Reaktionsgleichung

Hydrazine

methyl 4-pentylbicyclo[2.2.2]octane-1-carboxylate

water

→

4-pentylbicyclo[2.2.2]octane-1-carbohydrazide

Lösungsmittel

ethylene glycol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 17 h
2. 2
   Extraktionextracted with methylene chloride (3×600 mL)
3. 3
   WaschenThe combined extracts were washed twice with water, brine
4. 4
   Trocknendried (MgSO4)
5. 5
   Einengenconcentrated in vacuo

Vorschrift

Hydrazine (anhydrous, 103 mL, 88.7 mmol) was added to a solution of methyl 4-pentylbicyclo[2.2.2]octane-1-carboxylate (2-B) in ethylene glycol (180 mL) and the mixture was stirred under reflux for 17 h. After cooling to room temperature, the mixture was poured into water (1500 mL) and extracted with methylene chloride (3×600 mL). The combined extracts were washed twice with water, brine, dried (MgSO4) and concentrated in vacuo to provide 4-pentylbicyclo[2.2.2]octane-1-carbohydrazide (2-C). 1H NMR (500 MHz, CDCl3): δ 0.90 (t, 3H); 1.21 (m, 8H); 1.43 (m, 6H); 1.74 (m, 6H); 3.85 (broad s, 2H); 6.81 (broad s, 1H) ppm.

Quelle