Reaktion #510069

Reaktionsgleichung

acrylate

olopatadine hydrochloride

isopropyl myristate

olopatadine hydrochloride

olopatadine hydrochloride

ethyl acetate

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Olopatadine

Lösungsmittel

toluene

ethyl acetate toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order
2. 2
   workup.DISSOLUTIONto dissolve
3. 3
   workup.ADDITIONwere sequentially added to the mixture
4. 4
   workup.ADDITIONThe mixture was fully mixed
5. 5
   Sonstigedegassed
6. 6
   Sonstigewas completely evaporated
7. 7
   Sonstigefor 8 to 12 hours
8. 8
   Sonstigeat about 40° C.
9. 9
   Sonstigeto give adhesive
10. 10
    Sonstigepreparation

Vorschrift

The obtained olopatadine hydrochloride was mixed with about 2 mL of ethyl acetate. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve or disperse olopatadine hydrochloride, and fully mixed with isopropyl myristate. Acrylic pressure sensitive adhesive 3.7125 g (PE-300; acrylate copolymer; solid content of 40% by weight (ethyl acetate/toluene mixed solvent): 1.485 g; Nippon Carbide Industries Co., Ltd.) and crosslinking agent 0.015 g (CK401; metal chelate; solid content of about 10% by weight (toluene solvent): 0.0015 g; Nippon Carbide Industries Co., Ltd.) were sequentially added to the mixture. The mixture was fully mixed and degassed. The mixture was spread over release liner using metering knife or baker applicator, and stood until the organic solvent was completely evaporated. Subsequently, support was laid over the release liner and compressed using roller, and subjected to crosslinking in temperature controlled bath for 8 to 12 hours at about 40° C. to give adhesive preparation comprising olopatadine hydrochloride.

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