Reaktion #50968

Reaktionsgleichung

morpholine4-carboxylic acid 1-benzyloxycarbonyl-2-[2-(4-fluorophenyl)acetyl]-pyrazolidin-4-yl ester

→

desired product

morpholine-4-carboxylic acid 1-[2-(4-fluorophenyl)acetyl]-pyrazolidin-4-yl ester

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe flask flushed with nitrogen
2. 2
   workup.ADDITIONthen charged with 10% palladium on carbon (103 mg)
3. 3
   FiltrationThe reaction mixture is filtered through a pad of Celite
4. 4
   Waschenrinsed with ethyl acetate (100 ml.)
5. 5
   Einengenconcentrated in vacuo

Vorschrift

morpholine4-carboxylic acid 1-benzyloxycarbonyl-2-[2-(4-fluorophenyl)acetyl]-pyrazolidin-4-yl ester, 40, (512 mg, 1.09 mmol) is dissolved in methanol (10 mL) and the flask flushed with nitrogen then charged with 10% palladium on carbon (103 mg). The reaction mixture is vigorously stirred and hydrogenated at 1 atmosphere for 2.5 hours at room temperature. The reaction mixture is filtered through a pad of Celite, rinsed with ethyl acetate (100 ml.) and concentrated in vacuo to afford 354 mg of the desired product as a white powder.

Quelle