Reaktion #50931

Reaktionsgleichung

hydrochloric acid

sodium hypochlorite

1-indane-5-yl-ethanone

sodium bisulfite

→

5-indancarboxylic acid

Ausbeute 95.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby cooling to rt
2. 2
   FiltrationThe solid that forms is filtered
3. 3
   Waschenwashed several times with water
4. 4
   SonstigeThe solid is dried under high vacuum at 60° C. for 5 h

Vorschrift

To a stirred 6% aqueous sodium hypochlorite solution in an oil bath to 55° C. is added 1-indane-5-yl-ethanone (1.0 g, 6.2 mmol). The solution is stirred at 55° C. for 2 h, followed by cooling to rt. Solid sodium bisulfite is added until the solution becomes clear. The mixture is diluted with water, followed by aqueous hydrochloric acid (6.0 M). The solid that forms is filtered and washed several times with water. The solid is dried under high vacuum at 60° C. for 5 h to afford 5-indancarboxylic acid as a white solid (0.96 g, 95%): 1H NMR (CDCl3) δ 8.0, 7.9, 7.3, 3.0, 2.1.

Quelle