Reaktion #508817

Reaktionsgleichung

N,N-Diisopropylethylamine

4-(4-aminophenyl)-3-morpholinone

methyl chloroformate

→

methyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate

Ausbeute 95.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe resulting thick suspension was stirred for another 1 h
2. 2
   Filtrationfiltered through a Buchner funnel
3. 3
   WaschenThe solid was washed with CH2Cl2 (2×75 mL)
4. 4
   Sonstigedried under vacuum

Vorschrift

N,N-Diisopropylethylamine (27.2 mL, 156.08 mmol) was added over 3 min to a stirred suspension of 4-(4-aminophenyl)-3-morpholinone (2, 25 g, 130.07 mmol) in CH2Cl2 (750 mL). The reaction mixture was stirred at room temperature for 15 min and methyl chloroformate (11.6 mL, 149.58 mmol) was added drop-wise over 10 min. The resulting thick suspension was stirred for another 1 h and filtered through a Buchner funnel. The solid was washed with CH2Cl2 (2×75 mL) and dried under vacuum to obtain methyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate (5b, 30.92 g, 95%) as a crystalline solid.

Quelle