Reaktion #5088

Reaktionsgleichung

sulfuric acid

2,4-dimethyl-6-(2-phenylacryloyl)phenol

→

2,3-dihydro-4,6-dimethyl-2-phenyl-7-hydroxy-1H-inden-1-one

Ausbeute 70.3%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe whole mixture was stirred at room temperature for 1 hour
2. 2
   Extraktionextracted with 200 ml of methylene chloride
3. 3
   WaschenThe extract was washed with water
4. 4
   Trocknendried with anhydrous magnesium sulfate
5. 5
   Einengenwas concentrated under a reduced pressure
6. 6
   Sonstigeto obtain the residue
7. 7
   SonstigeThe residue was recrystallized from ethanol

Vorschrift

Into 15 ml of concentrated sulfuric acid, under ice-cooled condition with stirring, 3.0 g of 2,4-dimethyl-6-(2-phenylacryloyl)phenol was added gradually, then the whole mixture was stirred at room temperature for 1 hour. The reaction mixture was poured in 100 g of ice and extracted with 200 ml of methylene chloride. The extract was washed with water and dried with anhydrous magnesium sulfate, then was concentrated under a reduced pressure to obtain the residue. The residue was recrystallized from ethanol to obtain 2.11 g of 2,3-dihydro-4,6-dimethyl-2-phenyl-7-hydroxy-1H-inden-1-one.

Quelle