Reaktion #50862

Reaktionsgleichung

N-bromosuccinimide

7-chloroquinaldine

dibenzoylperoxide

→

title compound

2-bromomethyl-7-chloroquinoline

Lösungsmittel

CCl4

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe suspension was cooled
2. 2
   WaschenThe plug of silica gel was washed with 30% ether in hexane
3. 3
   Sonstigethe filtrate was evaporated

Vorschrift

A stirred suspension of N-bromosuccinimide (9.0 g), 7-chloroquinaldine (9.0 g), dibenzoylperoxide (0.5 g ) in CCl4 (200 ml) at 90° was illuminated with a 225W sunlamp for 6 hours. The suspension was cooled and passed through a plug of silica gel. The plug of silica gel was washed with 30% ether in hexane and the filtrate was evaporated. Flash chromatography of the residue using 30% ether in hexane afforded the title compound.

Quelle