Reaktion #50833

Reaktionsgleichung

hydrochloric acid

5-(p-cyanophenyl)-5-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

sodium hydroxide

→

title compound

5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is refluxed for 1 h
2. 2
   Temperaturcooled
3. 3
   Sonstigeevaporated
4. 4
   SonstigeThe residue is partitioned between water and ethyl acetate
5. 5
   SonstigeThe organic layer is separated
6. 6
   Trocknendried over sodium sulfate
7. 7
   Sonstigeevaporated

Vorschrift

A solution of 1.65 g of 5-(p-cyanophenyl)-5-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in 10 ml of methanol containing 0.2 g of sodium hydroxide is stirred for 3 h at room temperature and 5 ml of 1N hydrochloric acid is added. The reaction mixture is refluxed for 1 h, cooled and evaporated. The residue is partitioned between water and ethyl acetate. The organic layer is separated, dried over sodium sulfate and evaporated to yield the title compound.

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