Reaktion #50826

Reaktionsgleichung

5-(p-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

N,N-dimethylformamide

→

title compound

5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated under nitrogen at 120° for 11 h
2. 2
   TemperaturThe reaction mixture is cooled
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   TrocknenThe organic extracts are dried over sodium sulfate
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe resulting oil is chromatographed on silica gel with ethyl acetate

Vorschrift

A mixture of 85 mg of 5-(p-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 74 mg of cuprous cyanide in 1 ml of N,N-dimethylformamide is heated under nitrogen at 120° for 11 h. The reaction mixture is cooled, diluted with 10 ml of water and extracted with ethyl acetate. The organic extracts are dried over sodium sulfate and evaporated. The resulting oil is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.

Quelle