Reaktion #507936

Reaktionsgleichung

Methyl 2-chloro-4-methylbenzoate

Dibal-H

→

final compound

Ausbeute 82.6%

(2-chloro-4-methylphenyl)methanol

Ausbeute 82.6%

Lösungsmittel

Dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITThe mixture was left at 0° C. for 2H
2. 2
   Sonstigeat room temperature
3. 3
   Sonstigeovernight
4. 4
   Sonstigereaction
5. 5
   Sonstigewas quenched with Rochelle salt
6. 6
   Sonstigeleaving
7. 7
   Extraktionit was extracted with DCM
8. 8
   Sonstigedried
9. 9
   Einengenconcentrated

Vorschrift

Methyl 2-chloro-4-methylbenzoate (520 mg, 2.82 mmol) was dissolved in Dichloromethane (DCM) (15 mL) and at 0° C. Dibal-H (4.694 ml, 7.04 mmol) was slowly added. The mixture was left at 0° C. for 2H and then at room temperature overnight. Next morning HPLC showed no starting material remaining, reaction was quenched with Rochelle salt, and leaving under stirring for 1 hour and then it was extracted with DCM, dried and concentrated to afford 365 mg of the final compound, pure enough to be used in the next step.

Quelle