Reaktion #5078

ord-d330762a78a24610a29680bec14ad834

Reaktionsgleichung

CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Boc-Leu-Ala-OBzl
→
CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Boc-Leu-Ala-OBzl
CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
H-Leu-Ala-OBzl

Edukte

—
dipeptide
CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Boc-Leu-Ala-OBzl

Reagenzien

Keine

Lösungsmittel

O=C(O)C(F)(F)F
trifluoroacetic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeexcess trifluoroacetic acid was removed by evaporation
  2. 2
    workup.ADDITIONthe residue was treated with ether

Vorschrift

Boc-Leu-Ala-OBzl was prepared by the procedure for dipeptide synthesis in Example 2. Boc-Leu-Ala-OBzl (23.7 g, 57.7 mmoles) was dissolved in 40 mL of anhydrous trifluoroacetic acid. After 15 min, excess trifluoroacetic acid was removed by evaporation and the residue was treated with ether to yield H-Leu-Ala-OBzl.trifluoroacetic acid as a crystalline product (22.8 g).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242904uspto-grants-1993_09