Reaktion #507288

Reaktionsgleichung

D-serine

trityl chloride

trimethylsilyl chloride

→

titled product

N-trityl-D-serine

Lösungsmittel

dichloromethane

methanol

dichloromethane

triethyl amine

dichloromethane

methanol

Triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto form a suspension
2. 2
   Temperaturit was cooled to ambient temperature
3. 3
   TemperaturThe mixture was refluxed for 45 minutes at 35-40° C.
4. 4
   Temperaturcooled to 0° C
5. 5
   Sonstigeto reach at room temperature
6. 6
   workup.ADDITIONwas added at ambient temperature in 10-15 minutes
7. 7
   Sonstigethe solvent was recovered under vacuum at 40-45° C
8. 8
   SonstigeThe crude product obtained
9. 9
   Waschenwas washed with water (750 ml)
10. 10
    Filtrationfiltered
11. 11
    WaschenThe filtered product was further washed with 5% citric acid solution (750 ml)
12. 12
    Filtrationfiltered
13. 13
    SonstigeThe solid product obtained
14. 14
    Sonstigewas partitioned between water (750 ml) and hexanes (200 ml)
15. 15
    Filtrationfiltered
16. 16
    WaschenThe filtered solid was washed with hexanes (200 ml)
17. 17
    Sonstigedried

Vorschrift

To dichloromethane (500 ml), D-serine (50 g) was added at ambient temperature under nitrogen atmosphere to form a suspension and then trimethylsilyl chloride (180.91 g) was added to the suspension in 10-15 minutes at ambient temperature. The reaction mixture was refluxed at 35-40° C. for 20 minutes and then it was cooled to ambient temperature. To the reaction mixture, a solution of triethyl amine (168.50 g) in dichloromethane (50 ml) was added in 30-45 minutes at 25-30° C. The mixture was refluxed for 45 minutes at 35-40° C. and then cooled to 0° C. To this mixture, a solution of anhydrous methanol (22.83 g) in dichloromethane (50 ml) was added at 0° C. and the mixture was allowed to reach at room temperature. Triethylamine (48.14 g) was slowly added to it at 25-30° C. and then trityl chloride (132.63 g) was added in 3 lots to the mixture at an interval of 10 minutes. The reaction mixture was then stirred for 3 hours under nitrogen at ambient temperature. After completion of the reaction, methanol (76.12 g) was added at ambient temperature in 10-15 minutes and the solvent was recovered under vacuum at 40-45° C. The crude product obtained was washed with water (750 ml) and filtered. The filtered product was further washed with 5% citric acid solution (750 ml) and filtered. The solid product obtained was partitioned between water (750 ml) and hexanes (200 ml) and then filtered. The filtered solid was washed with hexanes (200 ml) and dried to obtain the titled product. Yield=135 gm.

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