Reaktion #50727

Reaktionsgleichung

Triethylamine

Boc-Leucine

triethylamine

carbonyl-diimidazole

→

desired product

[t-Butyloxycarbonyl)-L-Leucine N-Methoxy-N-methylamide

Lösungsmittel

dicloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITto be completely within an hour
2. 2
   Waschenwashed successively with 1N HCl
3. 3
   TrocknenThe organic solution was dried with magnesium sulfate
4. 4
   Sonstigethe solvent evaporated

Vorschrift

Triethylamine (10 ml) is added to a stirred solution of Boc-Leucine in dichloromethane. Then sequentially, carbonyl-diimidazole (10 mmol) are added followed by, N-dimethylhydroxyamine hydrochloride (11 mmol), and triethylamine (11 mmol). The reaction is monitored by TLC, was found to be completely within an hour. The mixture is diluted with dicloromethane (250 ml) and washed successively with 1N HCl, and a saturated sodium chloride solution. The organic solution was dried with magnesium sulfate, and the solvent evaporated to give the desired product (9.0 mmol yield).

Quelle