Reaktion #50707

Reaktionsgleichung

Water

8-Phenyloctyl bromide

5-methyl-2-hydroxy-1,3-benzenedicarboxaldehyde

potassium carbonate

→

title product

5-Methyl-2-(8-phenyloctyloxy)-1,3-benzenedicarboxaldehyde

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Extraktionthe mixture extracted with diethyl ether (2×40 ml)
3. 3
   SonstigeThe extracts were dried
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated to a yellow solid
6. 6
   SonstigeRecrystallisation from methanol (25 ml)

Vorschrift

8-Phenyloctyl bromide (2.69 g, 10 mmol) was added to a stirred mixture of 5-methyl-2-hydroxy-1,3-benzenedicarboxaldehyde (1.64 g, 10 mmol) and anhydrous potassium carbonate (1.38 g, 10 mmol) in dry dimethylformamide (20 ml) at room temperature under nitrogen. The suspension was heated to 80° C. for 3 hours then allowed to cool. Water (40 ml) was added and the mixture extracted with diethyl ether (2×40 ml). The extracts were dried, filtered and evaporated to a yellow solid. Recrystallisation from methanol (25 ml) gave the title product as pale yellow crystals, m.p. 59° C.

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