Reaktion #50695

Reaktionsgleichung

sodium

Diethyl malonate

sodium ethoxide

Isoamyl bromide

→

Sodium ethoxide

diethyl isoamylmalonate

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture was heated
2. 2
   Temperaturunder reflux overnight
3. 3
   workup.DISTILLATIONAfter the usual work-up, the resulting crude product was distilled under reduced pressure

Vorschrift

Sodium ethoxide was prepared from sodium metal (9.1 g) and freshly distilled absolute ethanol (250 ml). Diethyl malonate (63.5 g) was added to sodium ethoxide in ethanol, and the mixture was stirred at 60°-70° C. for 50 min. Isoamyl bromide (60 g) was added, and the reaction mixture was heated under reflux overnight. After the usual work-up, the resulting crude product was distilled under reduced pressure to give diethyl isoamylmalonate. Yield: 71.7 g (78%).

Quelle